Tool targets cancer-causing fusions weak spot

Scientists at St. Jude Children’s Research Hospital comprehensively characterized oncogenic fusions in pediatric cancer, providing proof-of-principle for genetic engineering-based therapies. The scientific foundation needed to work on curing a class of cancer-causing mutations is here, in the form of a tool from St. Jude Children’s Research Hospital. Computational biologists at St. Jude comprehensively categorized and identified the mechanism underlying oncogenic […]

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Can a drug used to treat liver disease help prevent SARS-CoV-2 infections and lessen COVID-19 severity?

SARS-CoV-2, the virus that causes COVID-19, attaches to a cellular receptor called angiotensin-converting enzyme 2 (ACE2), and activation of the farnesoid X receptor increases ACE2 expression. New research published in the Journal of Internal Medicine suggests that a drug that inhibits the farnesoid X receptor and is used to treat liver disease may decrease SARS-CoV-2 infections and reduce the severity […]

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USDA Scandal Fallout: ASPCA Sends Letter to USDA & Congress; Senior USDA Official Resigns

On March 16, 2023, the ASPCA sent an open letter to Secretary Tom Vilsack of the U.S. Department of Agriculture (USDA) and members of Congress to take immediate action to protect dogs from government-sanctioned cruelty following an appalling USDA cover-up of the Envigo case.  A little more than a week later, the Deputy Administrator of the problem-ridden Animal Care program […]

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Healthy sleep pattern may help offset asthma risk regardless of genetic susceptibility

Poor quality sleep may bolster a person's genetic susceptibility to asthma, potentially doubling their risk of being diagnosed with the condition, suggests a large UK Biobank study, published in the open access journal BMJ Open Respiratory Research. A healthy sleep pattern seems to be linked to a lower risk of asthma, prompting the researchers to suggest that spotting and treating […]

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Bayer Defeats Merck in Lawsuit Over Talc Liabilities

(Reuters) – A Delaware judge on Monday dismissed Merck & Co’s lawsuit seeking to hold Bayer AG responsible for more talc-related liabilities stemming from its $14.2 billion purchase of Merck’s consumer care business in 2014. Vice Chancellor Nathan Cook of the Delaware Chancery Court said the purchase agreement “clearly and unambiguously” left Merck liable for claims related to products, including […]

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GP burnout linked to higher opioid and antibiotic prescribing in England

Burnout in GPs has been linked to higher antibiotic and strong opioid prescribing, especially in the more deprived areas of the North of England, finds research from The University of Manchester. The study, published in the British Journal of General Practice links the prescribing behavior of GPs to signs of burnout such as emotional exhaustion, feeling detached from colleagues and […]

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