10,000 steps vs. power walking: Are they equally beneficial?

A large new study investigates the health effects of walking 10,000 steps a day or less. The researchers found that the risk of premature death decreases with every 2,000 steps people take. They also found a correlation between the number of daily steps and a reduced risk of developing dementia, heart disease, and cancer. Power-walking also adds additional benefits and […]

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A new study from the Garvan Institute of Medical Research shows how rises in core body temperature may trigger the inflammatory flares in people with a rare genetic autoinflammatory disease. The recessive disorder, called mevalonate kinase deficiency (MKD), is caused by mutations in the gene for mevalonate kinase, an essential enzyme present in all cells in the body. Lack of […]

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New antiviral mechanism of action for an FDA-approved thiopurine known as 6-thioguanine

In a recent study published in PLoS Pathogens, researchers described a novel antiviral mechanism of action for an FDA (food and drug administration)-approved thiopurine known as 6-thioguanine (6-TG). Study: Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions. Image Credit: Bacsica/Shutterstock Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has spurred efforts to repurpose drugs to […]

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Addiction management is key to treating heart infection in people who inject drugs

Managing a potentially deadly heart infection is complex in people who inject drugs, including opioids, stimulants, and others, and requires a unique approach to care including consultation with an addiction specialist, according to a new American Heart Association Scientific Statement published today in the Association’s flagship journal Circulation. Infective endocarditis is caused by bacteria that enter the bloodstream and settle […]

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Biological effects of nanoplastics in paints

The high rate of plastic usage throughout the world and its subsequent uncontrolled deposition in landfills and water bodies have a significant effect on the environment. Although plastics are resistant to biodegradation, larger plastics are converted to smaller pieces when subjected to mechanical abrasion in hydrolytic surroundings or under ultraviolet (UV) irradiation. When disintegrated plastics reach between one micrometer (µm) […]

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FDA OKs First Targeted Agent, Pemigatinib, for Rare Blood Cancer

The US Food and Drug Administration (FDA) has approved pemigatinib (Pemazyre), a selective fibroblast growth factor receptor inhibitor, for adults with relapsed or refractory myeloid/lymphoid neoplasms with FGFR1 rearrangement. The approval follows priority review of a supplemental New Drug Application submitted by the drug maker, Incyte, and marks the second indication for pemigatinib. The drug previously received accelerated FDA approval […]

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Final results of the PATHFINDER study by GRAIL on multi-cancer early detection tests announced

A recent press release by GRAIL, LLC announced the results of their interventional PATHFINDER study on the early detection of cancer using multi-cancer early detection (MCED) blood tests. The results were presented at the European Society for Medical Oncology (ESMO) Congress in Paris this year. Study: GRAIL Announces Final Results From the PATHFINDER Multi-Cancer Early Detection Screening Study at ESMO […]

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Prenatal exposure to high-dose folic acid is associated with a greater than twofold increased risk for cancer in children of mothers with epilepsy, new data from a Scandinavian registry of more than 3 million pregnancies suggests. The increased risk for cancer did not change after considering other factors that could explain the risk, pill identifier oxcarbazepine such as use of […]

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Uganda confirms seven cases of Ebola and one death

The health authorities in Uganda have recently announced an Ebola Virus Disease (EVD) outbreak in Mubende District, Uganda, located in the central part of the country. Study: Uganda declares Ebola Virus Disease outbreak. Image Credit: Crevis / Shutterstock.com What is EVD? EVD is a severe illness that affects humans and other primates and could be fatal if left untreated. The Ebola […]

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New study underscores need for COVID-19 booster shots for older adults

In a study of more than 80 men and women from Baltimore, Maryland, Johns Hopkins researchers have added to evidence that COVID-19 booster shots are essential for maintaining long-term immunity against infection, particularly among older adults. Results of the study, published Aug. 15 in Clinical Infectious Diseases, directly support the CDC vaccination guidelines recommending COVID-19 boosters, investigators say. A previous […]

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