Adult-born neurons grow more than their infancy-born counterparts

Adult-born neurons keep growing and contributing to brain flexibility long after neurogenesis declines, according to research in rats published in JNeurosci.

The dentate gyrus, a brain region involved in distinguishing memories, creates new neurons during adulthood—that much is clear. What remains unclear is how long adult neurogenesis takes place and how many neurons it creates. However, humans may not need neurogenesis to persist for the entirety of adulthood, because the brain gets the same memory benefits from neurons that are still growing up.

Cole, Espinueva et al. tracked neurogenesis by injecting rats’ dentate gyri with a retrovirus that incorporates itself into the DNA of dividing cells, making all the neurons born on injection day glow. Just like neurons born in infancy, adult-born neurons went through a standard six-week development period. But at the seven-week mark, growth markers like thicker dendrites reappeared, indicating an upcoming stage of growth.

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