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People with Lynch syndrome have a higher hereditary risk of colon cancer. Despite regular endoscopic surveillance, it remains elevated in those affected. Researchers at the National Center for Hereditary Tumor Diseases (NZET) at Bonn University Hospital (UKB) have now found that artificial intelligence (AI) can improve the effectiveness of colonoscopy in the presence of Lynch syndrome. The study results have been published online in the United European Gastroenterology Journal.

Hereditary non-polyposis colorectal cancer (HNPCC)—Lynch syndrome (LS) for short—is the most common hereditary colorectal cancer syndrome. Based on estimates, it is believed to affect approximately 300,000 individuals in Germany alone. LS is responsible for about 2–3% of all colon cancers. It is triggered by defects in genes responsible for repairing the human genetic material DNA. Children of those affected have a 50% risk of also having the pathologically altered hereditary disposition, technically known as a mutation, and thus also a high risk of developing colon cancer at a young age.

Therefore, como se toma el aciclovir de 800mg regular monitoring by means of colonoscopy is recommended here every one to two years. “However, despite such regular endoscopic monitoring, the risk of colorectal cancer remains elevated in those affected,” says Prof. Jacob Nattermann, head of the Hepatogastroenterology Section at UKB’s Medical Clinic I. The researchers explain this by the fact that colonoscopy still misses a considerable number of adenomas, the potential precursors of colorectal cancer. “Small and flat adenomas in particular are at risk of being overlooked even by experienced gastroenterologists,” says Prof. Nattermann.

Increased adenoma detection rate

Recent data suggest that artificial intelligence (AI)-assisted colonoscopy, also known as computer-aided detection (CADe), may help increase adenoma detection rates (ADR) in the general population.

“Therefore, the aim of our study was to evaluate the diagnostic performance of AI-assisted colonoscopy in patients with Lynch syndrome,” says Robert Hüneburg, senior physician at UKB’s Medical Clinic I.

In close collaboration with the Institute of Medical Informatics, Statistics and Epidemiology at the University of Leipzig, 46 LS patients were studied using standard endoscopy and 50 LS patients with AI-assisted colonoscopy between December 2021 and December 2022. Here, significantly more of the AI-assisted examinations (36%) detected adenomas than the standard examinations (26.1%).

“This was mainly due to significantly improved detection of flat adenomas,” Hüneburg says.

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