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Visceral larva migrans is a zoonotic infestation by certain nematode parasites which are found in dogs and cats. These are roundworm larvae of the species Toxocara canis (T. canis) and (less frequently) Toxocara cati (T. cati).

Toxocara canis second stage larvae hatch from eggs.

Mechanism of infection

When roundworms infest these animals, they live and lay eggs in the intestines. The eggs are passed out with the feces, which contaminate the soil where the droppings are laid. They are non-infective and become infective after undergoing a couple of molts in the soil, buy viagra plus over 2-4 weeks. At this stage they remain viable for years.

When this contaminated soil is ingested by humans, or the eggs in it come into contact with edibles, the eggs hatch in the human body. For instance, if fruits or vegetables are grown in this soil, they may have the eggs on them. Young children sometimes ingest soil when they have pica, or if they play in such places. Raw liver from these animals is also a route of larval transmission.

The incubation period in humans for visceral larva migrans is anywhere between 2 weeks to one year.

The larvae that emerge from the hatched eggs travel through the intestinal wall into the blood capillaries to reach different parts of the body, including the liver, lungs, eyes, brain or heart. In these organs, the worm larvae cause varying degrees of local inflammation leading to non-specific symptoms. This condition is referred to as visceral larva migrans. It was first described by Beaver and his coworkers in 1952.

Since dogs do not choose a specific spot to pass their stools in, visceral larva migrans involves T. canis larvae much more commonly than T. cati. Toxocara larvae cannot mature into adult worms in humans because they do not develop beyond the L2 stage of their life cycle outside their definitive hosts.

Symptoms

Symptoms of visceral larva migrans range from mild to life-threatening. They include:

• Allergic reactions such as itching and wheezing
• Abdominal pain
• Cough and breathlessness
• Fever

Factors which determine how serious the symptoms are may include:

• Allergic reactions to the larval antigens or products
• Number of exposures
• Number of larvae ingested
• Immunocompromised or hypersensitive host

Diagnosis

The diagnosis of this condition is by a history of potential exposure along with the symptoms of allergy or systemic complaints. The stool should be examined for roundworm eggs and larvae. Blood tests show a high white cell count. Specific toxocara antibodies are also high.

Examination may reveal an enlarged liver, pneumonitis, fever and cough, with raised white cell counts and immunoglobulin levels on blood tests.

Complications

In rare situations, brain, lung and heart complications may result from larval infestation. These include encephalitis, arrhythmias and breathlessness.

Prognosis

Toxocariasis is usually self-limiting and does not require treatment, but if required, antihelminthic drugs are given.

Prevention

Prevention of toxocariasis involves the following steps:

• Deworm all pet dogs and cats.
• Prevent your pets from dropping feces anywhere but designated spots which do not come into contact with people or edible plants.
• Ensure that everyone in your home washes their hands thoroughly after touching a dog or cat, or working outdoors.
• Never eat raw liver, whether from poultry, sheep or cattle.

References

1. https://medlineplus.gov/ency/article/000633.htm
2. http://web.stanford.edu/group/parasites/ParaSites2005/Toxocariasis/whole%20thing.htm
3. http://www.scielo.br/scielo.php?pid=S0021-75572011000200004&script=sci_arttext&tlng=en

Further Reading

• All Ocular Larva Migrans Content
• Ocular Larva Migrans
• Ocular Larva Migrans Symptoms and Causes
• Ocular Larva Migrans Diagnosis and Treatment
• All Roundworm Content

Written by

Dr. Liji Thomas

Dr. Liji Thomas is an OB-GYN, who graduated from the Government Medical College, University of Calicut, Kerala, in 2001. Liji practiced as a full-time consultant in obstetrics/gynecology in a private hospital for a few years following her graduation. She has counseled hundreds of patients facing issues from pregnancy-related problems and infertility, and has been in charge of over 2,000 deliveries, striving always to achieve a normal delivery rather than operative.