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Interstitial lung disease (ILD) is a broad group of lung diseases comprising of more than a hundred distinct disorders. All of these involve scarring or inflammation of the interstitial lung tissue and affect the volume of oxygen that can reach the bloodstream via the respiratory system.

They can be classified into different types, according to the cause of the disease, as described in more detail below.  

Image Credit: April stock / Shutterstock.com

Idiopathic

Although there are many known causes of interstitial lung disease, the most common of all types is idiopathic pulmonary fibrosis, which occurs without a known cause. Specific conditions that are classed as idiopathic may include:

• Idiopathic pulmonary fibrosis
• Non-specific interstitial pneumonia
• Desquamative interstitial pneumonia
• Respiratory bronchiolitis/interstitial lung disease
• Acute interstitial pneumonia
• Lymphoid interstitial pneumonia
• Cryptogenic organizing pneumonia

Idiopathic lung disease involves damage to the lung tissue resulting from scarring or inflammation without a clearly identifiable cause. There are likely to be several factors that play a role in the pathology, increasing lipitor dose such as genetic and environmental factors, but these are not always clear.

Environmental

In some cases, environmental or occupational factors may be responsible for the onset of interstitial lung disease, usually due to the inhalation of irritants.

For example, extrinsic allergic alveolitis, also known as Farmer’s lung, can lead to IPF as a result of the inhalation of dust in the farm environment. Similarly, black lung disease can affect coal miners that inhale coal dust in the occupational setting.

Pneumoconiosis is a condition that is a type of interstitial lung disease resulting from exposure to chemicals, such as silicon, asbestos or iron. Specifically, inhalation of asbestos can cause asbestosis, iron can cause siderosis and silicon can cause silicosis.  When these irritants are inhaled that can cause damage to the lung tissue and symptoms of ILD.

Individuals that smoke cigarettes are also at an elevated risk for ILD, as a result of the inhaled toxins.

Multisystem

There are also several systemic diseases that can result in interstitial lung disease, in addition to other effects around the body. Diseases of the connective tissues are the classic example of this type. Multisystem disease leading to IPF may include:

• Dermatomyositis
• Lupus erythematosus
• Polymyositis
• Rheumatoid arthritis
• Sclerosis
• Wegener’s granulomatosis

Sarcoidosis is a notable systemic condition that involves the formation of granulomas anywhere around the body, but commonly in the lungs to cause interstitial pulmonary disease.

Medication-Induced

Adverse drug reactions can also induce interstitial lung disease in some patients. The may include reactions from:

• Cytotoxic agents (e.g. methotrexate or bleomycin)
• Antiarrhythmic drugs (e.g. amiodarone)
• Antibiotics (e.g. nitrofurantoin, sulfonamides, infliximab)
• Statins

The damage to the lung tissue caused by these medications is highly variable, depending on the length and dose of the treatment.

Infection

Severe infections of the lungs can cause permanent damage to the respiratory system, leading to ILD. These infections may include:

• Pneumonia
• Tuberculosis
• Chlamydia trachomatis
• Respiratory syncytial virus

Familial

Familial pulmonary fibrosis, also known as familial interstitial pneumonia, accounts for a small percentage of patients that have idiopathic pulmonary fibrosis. This occurs when a particular gene mutation is associated with increased susceptibility to scarring and damage to the lungs.

Malignancy

Malignancy has been associated with ILD, due to the pathology of the condition and the treatments to manage it.

Lymphangitic carcinomatosis involves malignant growth in the lung tissue that can lead to the scarring and ILD. Chemotherapy and radiation therapy can both cause damage to the lungs and cause symptoms of ILD.

References

• http://www.nationaljewish.org/healthinfo/conditions/ild/types
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585700/
• https://www.blf.org.uk/Page/What-is-interstitial-lung-disease
• https://www.nlm.nih.gov/medlineplus/ency/article/000128.htm

Further Reading

• All Interstitial Lung Disease Content

Written by

Yolanda Smith

Yolanda graduated with a Bachelor of Pharmacy at the University of South Australia and has experience working in both Australia and Italy. She is passionate about how medicine, diet and lifestyle affect our health and enjoys helping people understand this. In her spare time she loves to explore the world and learn about new cultures and languages.