Genetic switches in tumor development may lead to new therapeutic target for colorectal cancer

Researchers at Kanazawa University report in Cancer Research how Kras and p53 mutations influence the tumor suppressor and promoter functions of a TGF- ß pathway. The findings may lead to a new approach for colorectal cancer therapy. Both the progression and the suppression of tumors are governed by biomolecular processes. Often, a particular process is involved in either cancer progression […]

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Clinical trial reveals dapagliflozin's impact on heart failure and type 2 diabetes management

In a recent study published in eClinicalMedicine, a group of researchers conducted a clinical trial on the effects of dapagliflozin on the urinary albumin-to-creatinine ratio (UACR) in patients with heart failure (HF) and type 2 diabetes mellitus (T2D). Study: DAPagliflozin for the attenuation of albuminuria in Patients with hEaRt failure and type 2 diabetes (DAPPER study): a multicentre, randomised, open-label, […]

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Researchers discover how rapid tendon regeneration occurs in newts

Reviewed A research group led by Nagoya University's Graduate School of Engineering has uncovered how rapid tendon regeneration occurs in newts. The research, published in the Journal of Orthopaedic Research, compared the regeneration mechanism of damaged tendons in newts with those in mice. In the future, their findings could help physicians to treat human athletes recovering from tendon injuries. Tendon […]

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Millions of kids in US have inadequate health care coverage

Inadequate health coverage is a particular problem for commercially insured children, according to a new study released by Columbia University Mailman School of Public Health. The research shows that coverage gaps are affecting publicly insured children as well. Until now, prior research had focused on documenting rates and trends in insurance consistency for children covered by all insurance types. The […]

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FDA Warns of Potentially Lethal Reaction to Seizure Meds

The antiseizure drugs levetiracetam (Keppra, Keppra XR, Elepsia XR, Spritam, generic) and clobazam (Onfi, Sympazan, generic) can cause a rare but serious drug hypersensitivity reaction that can be life threatening if not detected and treated promptly, the US Food and Drug Administration (FDA) warns in an alert issued today. Known as drug reaction with eosinophilia and systemic symptoms (DRESS), it […]

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Developing a positive outcome from negative emotions

December can be an especially stressful time of the year. The holiday to-do list may feel overwhelming. Disappointment can swell if the “magic” of the season doesn’t live up to expectations. Even the thought of spending the holidays with extended family can trigger feelings of anxiety. “Oftentimes, people feel guilty because society tells us that the holidays are supposed to […]

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Study IDs barriers to eye screening among adults with diabetes

Food insecurity, housing insecurity, mental health concerns, and the perceived importance of practitioner concordance are associated with a lower likelihood of receiving eye care among adults with diabetes, according to a study published online Nov. 16 in JAMA Ophthalmology. Rohith Ravindranath, from Stanford University in Palo Alto, California, and colleagues evaluated associations between visiting an eye care practitioner for diabetic […]

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