TOPLINE: The review highlights variation in estimates of ALS incidence and prevalence around the world and points to lack of registries in some areas that cause “gaps” in reporting. METHODOLOGY: Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disorder that affects upper and lower motor neurons. Although the epidemiology of ALS has been investigated for many years, a comprehensive picture […]

In a recent study published in the Cell Host & Microbe Journal, researchers used a diverse set of 5,230 gut metagenomes [gut microbiome reference (GMR) dataset] representing human populations from 13 countries, three continents, and different age groups to train a study model. Study: Enterosignatures define common bacterial guilds in the human gut microbiome. Image Credit: MeekoMedia/Shutterstock.com Introduction They used a metabolic […]

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An expansion of the Affordable Care Act that extends Medicaid eligibility to more people improved patient outcomes, prevention measures and screening access, according to a review of research published today in Circulation: Cardiovascular Quality and Outcomes, a peer-reviewed American Heart Association journal. A provision of the Affordable Care Act of 2010 extended Medicaid eligibility to all adults with incomes of […]

A recent study has unveiled the doorway that SARS-CoV2 uses to slip inside cells undetected. SARS-CoV-2 uses the receptor angiotensin-converting enzyme 2, or ACE2, to infect human cells. However, this receptor alone does not paint a complete picture of how the virus enters cells. ACE2 is like a doorknob; when SARS-CoV-2 grabs it and maneuvers it precisely, this allows the […]

Give credit to your dad's gene for keeping you safe during those long months in your mother's womb. Because without this genetic warrior, you might have succumbed to any number of viral infections that otherwise could be fatal to a fetus. A new paper published this week in the journal Cell Host & Microbe explains the mechanisms behind this anti-viral […]

An estimated 3 million patients visit emergency departments each year with acute chest pain and mildly elevated troponin levels. High levels of troponin, a protein, occur when the heart muscle is damaged from a heart attack. How best to evaluate and treat patients with chest pain with detectable or mildly elevated troponin remains unclear. Now, a new study from researchers […]

TOPLINE: The less US patients pay out of pocket for drugs that often have high co-pays, such as sodium-glucose cotransporter 2 (SGLT2) inhibitors or glucagon-like peptide-1 (GLP-1) agonists, the more adherent they are. METHODOLOGY: Review of 90,041 US adults who started a GLP-1 agonist (n = 39,149) or SGLT2 inhibitor (n = 50,892) in 2014-2020. Participants had type 2 diabetes, […]

Topical corticosteroids, also referred to as corticosteroids or cortisone, are the go-to treatment for many skin disorders including eczema, dermatitis and psoriasis. They can be found in various forms such as creams, ointments, and solutions. These medications work by entering the skin cells and mimicking natural hormones, blocking inflammation and constricting blood vessels. Topical corticosteroids come in different strengths, from […]

There's a bouncer in everyone: The blood-brain barrier, a layer of cells between blood vessels and the rest of the brain, kicks out toxins, pathogens and other undesirables that can sabotage the brain's precious gray matter. When the bouncer is off its guard and a rowdy element gains entry, a variety of conditions can crop up. Barrier-invading cancer cells can […]