New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London has used an assessment of gene expression involved in the immune response to show that there could be more patients with MDD with activated immune systems than research has previously estimated. By identifying the molecular mechanisms involved in this association, the research could pave the […]

In response to a randomized trial that associated elective revascularization for ischemia with an increase in noncardiac mortality versus medical therapy alone, a meta-analysis with a far larger dataset challenges this assertion, suggesting the initial conclusion is due to a type 1 error. With data from nearly 17,000 patients in 18 randomized trials, the meta-analysis showed no signal for increased […]

Despite growing numbers of people affected by Alzheimer’s disease, the mechanisms by which it affects the brain remain debated. This means that developing early diagnostic tests is challenging, which affects the development of clinical trials to test potential treatments. A recent study has suggested changes to the retina could shed some light on the progression of Alzheimer’s disease. One of […]

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While it can take years for the pharmaceutical industry to create medicines capable of treating or curing human disease, a new study suggests that using generative artificial intelligence could vastly accelerate the drug-development process. Today, most drug discovery is carried out by human chemists who rely on their knowledge and experience to select and synthesize the right molecules needed to […]

A ground-breaking study by Loughborough University and the University of Oxford has led to the development of a small molecule probe that could deepen our understanding of a crucial cellular messenger and lead to the development of new therapeutic drugs. The research paper – recently highlighted as Pick of the Week in the Royal Society of Chemistry's flagship journal, Chemical […]

WASHINGTON – Abrocitinib demonstrated an acceptable long-term safety profile in adolescents with moderate to severe atopic dermatitis (AD) in an integrated safety analysis of 635 adolescents and over 1,000 patient-years of exposure, Lawrence F. Eichenfield, MD, reported at the annual Revolutionizing Atopic Dermatitis conference. In March 2023, the oral Janus kinase 1 (JAK1) inhibitor was approved by the Food and Drug Administration for treating […]

In a new study, researchers at Uppsala University have investigated how junk food affects sleep. Healthy participants consumed an unhealthier as well as a healthier diet in a randomized order. After the unhealthier diet, the quality of the participants' deep sleep had deteriorated, compared with those who had followed the healthier diet. The results have been published in the journal […]

Over half of British women feel their day-to-day life has changed, with many experiencing a knock to their confidence – after dealing with bladder leaks, a study has found. The issue affects one in three women in the UK, with a fifth not feeling confident in how to manage it. More than a third (37%) feel they have been held […]

Cardiovascular disease — the No. 1 cause of death among people 65 and older — is poised to become more prevalent in the years ahead, disproportionately affecting Black and Hispanic communities and exacting an enormous toll on the health and quality of life of older Americans. The estimates are sobering: By 2060, the prevalence of ischemic heart disease (a condition […]