Retinol disruption and the role of vitamin A metabolism in colon cancer

A new research perspective was published in Oncotarget, titled “Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism.” Colon cancer (CRC) is one of the most common malignancies and is a leading cause of cancer-related deaths worldwide. While the tumor microenvironment (TME) supports tumor growth and immune escape through tumor-promoting inflammation, […]

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Researchers determine bariatric surgery lowers health risks for people with common liver disorder

Researchers at West Virginia University have uncovered critical data showing bariatric surgery as a treatment method for patients with nonalcoholic fatty liver disease has a significant impact on improving clinical outcomes. The study, led by Dr. Shailendra Singh, included thousands of patients diagnosed with NAFLD, a condition that is seeing an upsurge and contributes to multiple other afflictions. While bariatric […]

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Can childhood trauma cause insomnia in adults?

Adverse childhood experiences (ACEs) are negative experiences such as emotional or physical abuse, sexual abuse, neglect, exposure to parental substance abuse, mental illness, or criminal behavior. These experiences, especially if they occur multiple times, have a devastating effect on the adult’s emotional functioning, increasing the risk of depression, anxiety, addiction, or suicidality. Knowing that ACEs might create vulnerability for a […]

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Pfizer Leans on COVID Products to Top Estimates

(Reuters) – Pfizer Inc on Tuesday reported higher-than-expected first-quarter revenue and profit, buoyed by demand for its COVID-19 products, and reaffirmed its 2023 earnings forecast as it banks on newer drugs to contribute to growth later this year. The company has said it expects 2023 to be a low point for COVID product sales, before potentially returning to growth in […]

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Is there an association between physical activity, sedentary behavior, and sleep with well-being in older adults?

A recent study published in the Journal of Activity, Sedentary, and Sleep Behaviors described 24-hour behaviors and their relationship with mental well-being in older adults. Study: To be well or not to be well: compositional associations of physical activity, sedentary behaviour and sleep with mental well-being in Flemish adults aged 55+ years. Image Credit: Kzenon/Shutterstock.com Background Aging is typically associated with a […]

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