Study reveals DCAF1 protein's role in colon cancer development through EZH2 phosphorylation

Initially, the DDB1 and CUL4 Associated Factor 1 (DCAF1) was identified as a protein that interacts with human immunodeficiency virus 1 (HIV-1) virion-associated protein (Vpr) and regulates cell cycles and cell proliferation. Although most research related to DCAF1, also known as HIV-1 Vpr binding protein (VprBP), has reported on its adaptor function in the Cullin 4 A E3 ubiquitin ligase […]
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