Discovery could lead to effective treatments for acute alcohol intoxication

A shot of a liver-produced hormone called FGF21 sobered up mice that had passed out from alcohol, allowing them to regain consciousness and coordination much faster than those that didn't receive this treatment, UT Southwestern researchers report in a new study. The findings, published in Cell Metabolism, could lead to effective treatments for acute alcohol intoxication, which is responsible for […]

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‘Other’ race/ethnicity linked to higher suicide and overdose risk in military members with mild TBI

Previous studies have reported high rates of death by suicide and drug overdose—including opioid overdose—in military service members with a history of mild traumatic brain injury (mTBI). A new study finds that those risks are highest among military members with mTBI who identify their racial/ethnic status as “Other,” as opposed to standard racial/ethnic categories. The study is published in the […]

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Using organ-on-a-chip technology to elucidate the liver pathophysiology of COVID-19 patients

SARS-CoV-2 infects and causes damage to multiple organs in COVID-19 patients. In particular, liver damage has been associated with COVID-19 severity. However, an understanding of the liver pathophysiology of these patients remains largely incomplete. To investigate this pathophysiology, the group developed liver models that mimic the liver around blood vessels or bile ducts using organ-on-a-chip technology. Human hepatocytes and cholangiocytes […]

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Gene variants linked to cerebral arachnoid cysts overlap with developmental disorders, autism, and epilepsy

The most common type of brain cyst (arachnoid) has no known cause. New research investigating patients with these cysts has found something unexpected—a potential genetic link. A team led by Yale University School of Medicine has gathered health history and exome data (sequences from all the protein-coding genes) from 617 trios—children with confirmed cases of arachnoid cysts and their parents—along […]

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Novel role of RNA editing by ADAR2 in core binding factor acute myelogenous leukemia

A team of researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS), co-led by Professor Daniel G. Tenen and Associate Professor Polly Chen Leilei, made an unprecedented discovery of a hitherto unappreciated mechanism leading to ADAR2 (adenosine deaminases acting on RNA) dysregulation in core binding factor acute myelogenous leukemias (CBF-AML), and highlighted […]

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