A recent study published in the Cell Chemical Biology Journal described a small molecule inhibitor of proliferating cell nuclear antigen (PCNA) that selectively kills cancer cells. Study: Small molecule targeting of transcription-replication conflict for selective chemotherapy. Image Credit: Lightspring/Shutterstock.com Background PCNA is a conserved multi-faceted protein in eukaryotes with a critical role in DNA replication and repair and has been historically used […]

Reviewers’ Notes Function and form are deeply intertwined in biology. Knowing how organisms grow, adapt and reproduce requires understanding their physical structures. Hence the transformative power of the microscope across the past four centuries of science. Microscopy, or the field of microscope use, can now reveal the tiniest of structures through techniques such as microcrystal electron diffraction, or MicroED. Instead […]

Childhood trauma, such as abuse, emotional neglect, and exposure to domestic violence may heighten a woman’s subsequent risk of pregnancy complications, and of giving birth to a low birthweight or premature baby, finds a pooled data analysis of the available evidence, published in BMJ Open. The risks of pregnancy related diabetes, high blood pressure, depression/anxiety and of giving birth to […]

Peptide YY (PYY), a hormone produced by gut endocrine cells that was already known to control appetite, also plays an important role in maintaining the balance of fungi in the digestive system of mammals, according to new research from the University of Chicago. In a study titled, “Peptide YY: a Paneth cell antimicrobial peptide that maintains Candida gut commensalism,” published […]

J.D. Butler was planning a future with his girlfriend at his favorite New York City restaurant when that future came to a sudden, crushing halt. “They were planning on when she was moving in and arranging floor plans on the table, with where the furniture was going to go,” said his mother, Karen Butler, a lifelong New York resident. “And […]

Mark Zuckerberg reveals his monster McDonald’s order and claims he eats more than 4,000 calories a DAY Mark Zuckerberg eats 4,000 calories a day to compensate for his fitness routine He also has a lengthy McDonald’s order that’s more than 2,500 calories READ MORE: What Elon and Mark Zuckerberg could eat before their cage fight Tech mogul Mark Zuckerberg has revealed […]

Sonia Hassan and Hala Ouweini, Wayne State University Every two minutes, in about the time it takes to read a page of your favorite book or brew a cup of coffee, a woman dies during pregnancy or childbirth, according to a February 2023 report from the World Health Organization. The report reflects a shameful reality in which maternal deaths have […]

For some of us, no matter how consistently we train, running never seems to get any easier—while others appear to be naturally gifted and can run for miles with ease. Part of this comes down to factors such as the kind of training you do or your diet, but our recent study has shown that genetics may also explain why […]

TOPLINE: Conflicts of interests in rheumatology research — particularly for clinical trials — are often incorrectly reported, according to a new analysis. METHODOLOGY: Researchers reviewed the first 50 clinical research reports, reviews, and editorials published in 2019 by Arthritis & Rheumatology, Arthritis Care & Research, and Seminars in Arthritis & Rheumatism. They cross-checked disclosures from the first, second, and last […]

In a recent study published in the Scientific Reports Journal, researchers determined the association between regular physical exercise based on virtual reality (VR) and the development of depression and anxiety symptoms among hemodialysis (HD) patients. Study: Impact of virtual reality exercises on anxiety and depression in hemodialysis. Image Credit: OleksandrKhmelevskyi/Shutterstock.com Background Anxiety is a common psychiatric symptom in individuals suffering from end-stage […]