The crucial role of zinc depletion in the action of a key antimalarial drug against the deadliest malaria parasite has been uncovered by a team led by RIKEN researchers. This finding provides valuable insights for developing new drugs against the disease. Their work is published in the journal ACS Infectious Diseases. Malaria poses a significant threat to nearly half of […]

Researchers analyzed data for patients who participated in the study for at least 90 days, with a range of 90-721 days for all patients. The average length of participation was 227 days. 31% of all patients had controlled blood pressure when they enrolled in the study, compared to 61% with controlled blood pressure at the end of the study period. […]

Reviewers’ Notes Rochester Institute of Technology researchers are improving non-invasive treatment options for degenerative disc disease, an ailment that impacts 3 million adults yearly in the U.S., according to the Mayo Clinic. Using state-of-the-art gene editing technology in mesenchymal stem cells, the researchers will add to the growing field of regenerative medicine, the process of producing cellular therapies to alleviate […]

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A significant portion of mammalian genomes are composed of retrotransposable elements (REs). Unlike the previous hypothesis that these are “junk DNA,” recent studies have shown that REs such as endogenous retroviruses (ERVs) and long interspersed nuclear element 1 (LINE1) play essential roles in embryonic stem cells (ESCs) and during embryogenesis. An increasing body of studies have shown that ERVs are […]

<img class="aligncenter" src="https://scx1.b-cdn.net/csz/news/800a/2023/new-study-reversing-ag.jpg" alt="New study: Reversing aging in the blood stem cells and the immune system" title="UA in vitro treatment reverses age-associated defects in HSCs. a, HSCs isolated from old mouse (100 weeks) BM were cultured for 3 days in the presence of 20 μM UA. After culture, 2,000 cells were transplanted in lethally irradiated primary recipient mice together with BM […]

Many of the drugs we use today started their journey from bench to bedside in a computer. But this is certainly not the case for all drugs. Indeed, many have exotic origins, including the blockbuster drugs Wegovy and Ozempic, which were inspired by the venom of the Gila monster. Scientists found that a hormone in the Gila monster’s venom called […]

Researchers at the University of Pittsburgh analyzed thousands of human genomes to find new gene variations responsible for controlling the levels of blood plasma molecules linked to Alzheimer’s disease risk. The findings, published recently in Molecular Psychiatry, could contribute to the future development of simple blood tests for the disease. Led by Ilyas Kamboh, Ph.D., professor of human genetics and […]

TOPLINE Biochemical recurrence (BCR) falls short as a reliable surrogate for overall survival in localized prostate cancer trials and may not be a suitable primary endpoint. METHODOLOGY In trials of localized prostate cancer, BCR remains a controversial surrogate endpoint for overall survival. The meta-analysis included 10,741 patients from 11 randomized clinical trials; the median follow-up was 9.2 years. Interventions included […]

In a study of US adolescents, both victims and perpetrators of cyberbullying were more likely than other youth to experience eating disorder symptoms. The findings are published in the International Journal of Eating Disorders. In the study of 10,258 adolescents aged 10–14 years, participants answered questions about whether they had experienced cyberbullying victimization and perpetration, as well as whether they […]