Aggressive marketing of OxyContin in the mid-1990s not only fueled the opioid crisis but also the spread of infectious diseases associated with injection drug use, a new analysis shows. The uptick in rates of infectious diseases, namely, hepatitis and infective endocarditis, occurred after 2010, when OxyContin maker Purdue Pharma reformulated OxyContin to make it harder to crush and snort. This […]

Some doctors need a trip to the gym or a run after a long shift. Others might have a drink. And some others prefer a bit…more. Each June in Boulder, Colorado, a unique subset of doctors gathers at the International Extreme Sports Medicine Congress for two days of learning. They examine the intricacies of treating patients who participate in extreme […]

Aug. 1, 2023 would have been Henrietta Lacks’s 103rd birthday. It was also the day the Lacks family reached a settlement with Thermo Fisher Scientific, the biotech company that used and profited from her “HeLa” cells. Though the details remain confidential, this settlement is a long-awaited moment of justice and victory for Lacks and her family. Lacks’s story is well […]

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Reviewers’ Notes What if there was a more effective way to coach and inspire your employees? Athletes? Students? Even your kids? A new study by a team of researchers from Case Western Reserve University suggests there is. Their newly published work used neuroimaging to peer into the brains of participants as they responded to two different styles of coaching. The […]

Reviewers’ Notes Function and form are deeply intertwined in biology. Knowing how organisms grow, adapt and reproduce requires understanding their physical structures. Hence the transformative power of the microscope across the past four centuries of science. Microscopy, or the field of microscope use, can now reveal the tiniest of structures through techniques such as microcrystal electron diffraction, or MicroED. Instead […]

Reviewers’ Notes Neurologist Beau Ances, MD, PhD, talks with his patient, Adam Kloppenberg, who has Down syndrome, at Washington University School of Medicine in St. Louis. People with Down syndrome are at very high risk of developing Alzheimer's disease. Ances is involved in a project led by Jason Hassenstab, PhD, how much tramadol for back pain an associate professor of […]

Some clinicians say it’s “confusing” and “ridiculous” to change the name and diagnostic criteria of an established liver disease, while others bemoan the seemingly political reasons why it happened. Yet recently, 236 panelists from 56 countries decided that the terms nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) rely on “exclusionary confounder terms and the use of potentially stigmatizing […]

Each cell in the body stores its genetic information in DNA in a stable and protected form that is readily accessible for the cell to carry on its activities. Nevertheless, mutations—changes in genetic information—occur throughout the human genome and can have a powerful influence on human health and evolution. “Our team is interested in a classical question about mutation—why do […]

Reviewers’ Notes Dopamine: It's not just for rewards anymore. In a new Northwestern University-led study, researchers identified and recorded from three genetic subtypes of dopamine neurons in the midbrain region of a mouse model. Although there is a long-standing, common assumption that most -; if not all -; dopamine neurons solely respond to rewards or reward-predicting cues, the researchers instead […]