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Individuals with chronic kidney disease (CKD) are vulnerable to developing severe forms of COVID-19, and acute kidney injury is a common complication of COVID-19. A recent analysis examined the temporal effects of pre-existing CKD and other medical conditions on COVID-19 outcomes by waves throughout the pandemic. The findings will be presented at ASN Kidney Week 2022 November 3–November 6.

Investigators identified 64,246 COVID-19 cases during 4 waves at Columbia University Medical Center in New York City, with 8% being severe and 18% requiring hospitalization. Among the major findings:

• The risk of severe COVID-19 was associated with pre-existing CKD, doctor of oriental medicine florida daytona heart disease, diabetes, and hypertension in most waves; and lung disease, obesity, and cancer in at least one wave.
• Acute kidney injury occurred in 49% of severe cases and 35% of hospitalized ones.
• The risk of acute kidney injury was associated with heart failure, obesity, diabetes, and cancer in most waves; and CKD, coronary artery disease, hypertension, and stroke in one or two waves.

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