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<img class="aligncenter" src="https://scx1.b-cdn.net/csz/news/800a/2023/fundamental-understand.jpg"
alt="Fundamental understanding of a molecule‘s normal function could inform treatments for a variety of brain disorders"
title="A truncated isoform of PDGFRβ was getected alongside full-length receptors across a range of murine tissues at different ages. (A) Representative images of a Western blot for proteins from select murine tissues at postnatal day 21 (P21) (from n = 3 biological replicates, both sexes) detected by immunolabeling for PDGFRβ and β-actin–lane 1: molecular size marker (M), lane 2: skeletal muscle (Skel. Musc.), lane 3: heart, lane 4: intestine, lane 5: liver, lane 6: blood serum, propecia pcos lane 7: kidney, lane 8: brain. (B) Graph of the ratio of integrated densities for bands at the 32 kDa size range relative to β-actin bands for each tissue indicated, all of which were normalized to the skeletal muscle samples. Bars are averages with standard deviations. (C) Representative images of a Western blot for proteins from select murine tissues at postnatal day 90 (P90) (from n = 3 biological replicate, both sexes) detected by immunolabeling for PDGFRβ and β-actin–lane 1: molecular size marker (M), lane 2: skeletal muscle (Skel. Musc.), lane 3: heart, lane 4: intestine, lane 5: liver, lane 6: blood serum, lane 7: kidney, lane 8: brain. (D) Graph of the ratio of integrated densities for bands at the 32 kDa size range relative to β-actin bands for each tissue indicated, all of which were normalized to the skeletal muscle samples. Bars are averages with standard deviations. Credit: Biomolecules (2023). DOI: 10.3390/biom13040711″ width=”800″ height=”424″>

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