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Aug. 1, 2023 would have been Henrietta Lacks’s 103rd birthday. It was also the day the Lacks family reached a settlement with Thermo Fisher Scientific, the biotech company that used and profited from her “HeLa” cells. Though the details remain confidential, this settlement is a long-awaited moment of justice and victory for Lacks and her family. Lacks’s story is well […]

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New PCNA inhibitor AOH1996 shows selective cancer cell killings and tumor suppression potential

A recent study published in the Cell Chemical Biology Journal described a small molecule inhibitor of proliferating cell nuclear antigen (PCNA) that selectively kills cancer cells. Study: Small molecule targeting of transcription-replication conflict for selective chemotherapy. Image Credit: Lightspring/Shutterstock.com Background PCNA is a conserved multi-faceted protein in eukaryotes with a critical role in DNA replication and repair and has been historically used […]

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New technique enables high-resolution analysis of DNA

Reviewers’ Notes Function and form are deeply intertwined in biology. Knowing how organisms grow, adapt and reproduce requires understanding their physical structures. Hence the transformative power of the microscope across the past four centuries of science. Microscopy, or the field of microscope use, can now reveal the tiniest of structures through techniques such as microcrystal electron diffraction, or MicroED. Instead […]

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Reviewers’ Notes What if there was a more effective way to coach and inspire your employees? Athletes? Students? Even your kids? A new study by a team of researchers from Case Western Reserve University suggests there is. Their newly published work used neuroimaging to peer into the brains of participants as they responded to two different styles of coaching. The […]

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Reviewers’ Notes Function and form are deeply intertwined in biology. Knowing how organisms grow, adapt and reproduce requires understanding their physical structures. Hence the transformative power of the microscope across the past four centuries of science. Microscopy, or the field of microscope use, can now reveal the tiniest of structures through techniques such as microcrystal electron diffraction, or MicroED. Instead […]

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Reviewers’ Notes Neurologist Beau Ances, MD, PhD, talks with his patient, Adam Kloppenberg, who has Down syndrome, at Washington University School of Medicine in St. Louis. People with Down syndrome are at very high risk of developing Alzheimer's disease. Ances is involved in a project led by Jason Hassenstab, PhD, how much tramadol for back pain an associate professor of […]

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Some clinicians say it’s “confusing” and “ridiculous” to change the name and diagnostic criteria of an established liver disease, while others bemoan the seemingly political reasons why it happened. Yet recently, 236 panelists from 56 countries decided that the terms nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) rely on “exclusionary confounder terms and the use of potentially stigmatizing […]

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