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Polyenes are among the most commonly used broad-spectrum antifungals but have significant associated renal toxicity. Attempts to develop newer drugs of the same class without these adverse effects led to nothing, mostly because of the perception that their antifungal activity was based on membrane permeabilization. Study: Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal. Image Credit: Fahroni/Shutterstock.com Amphotericin B […]

By Keynote ContributorCrystal Girod Senior Product ManagerBeckman Coulter Life Sciences Written by Keynote Contributor, Crystal Girod, Senior Product Manager at Beckman Coulter Life Sciences.  Proteomics is the area of research that studies protein expression, interactions, function, structure, and post-translational modifications. It can detect and quantify all the modifications and complex interactions of the proteins within a sample, which means this technique holds […]

Researchers at Weill Cornell Medicine have uncovered a novel route to stimulate the growth of healthy insulin-producing pancreatic beta cells in a preclinical model of diabetes. The findings hold promise for future therapeutics that will improve the lives of individuals with type 2 diabetes—a condition that affects more than half a billion people worldwide. This study, published in the Journal […]

I’m a psychologist – here’s how to tell if your child has ADHD or if they’re just a livewire It can be tricky for parents to know whether their child is among 5% with ADHD While often linked to ‘disruptive’ and ‘naughty’ behaviour, it is far more complex ADHD awareness and diagnoses are on the rise. But it can still be […]

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The investigational anti-amyloid drug donanemab (Eli Lilly) has similar clinical efficacy in apolipoprotein E ε4 (APOE4) heterozygous and homozygous carriers and noncarriers at high risk of Alzheimer’s disease (AD), new data from the TRAILBLAZER-ALZ 2 study show. “It’s important to understand whether APOE genotype affects rates of clinical decline in our clinical trial populations and if it affects efficacy of amyloid-targeting […]

An international team has for the first time researched the longevity of neutralizing antibodies in HIV-1-infected people. Currently, it is assumed that an HIV-1 vaccine can only be effective if it produces these antibodies in vaccinated humans. The findings improve understanding of the dynamics of such antibodies and are an important building block for further research into an HIV-1 vaccine. […]