New platform technology bridges the gap between microscopic analysis and multiplex imaging

Researchers at the Ludwig Center at Harvard have developed a platform technology for imaging that enables integration of the methods of microscopic analysis long employed in pathology laboratories with the visualization of multiple molecular markers in individual cells that is now rapidly advancing in research labs. The latter capability, known as "multiplex" imaging, promises to revolutionize cancer diagnostics by exposing […]

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Stem cell model of human brain development suggests embryonic origins of Alzheimers disease

Alzheimer’s disease (AD) mainly affects the older population. Recent research found early disease signs in cell culture models of early human brain development, raising the possibility that the disease has its origins much earlier in life, possibly during embryogenesis—the formation and development of an embryo. Alzheimer’s disease is a highly prevalent, debilitating, and potentially fatal neurodegenerative disease with limited treatment […]

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Mixed Picture of Benzodiazepine-Related Toxicity in Ontario

The rate of benzodiazepine-related toxicity in Ontario, Canada, has decreased overall but has increased among young people, data indicate. In a population-based, cross-sectional study that included almost 26,000 patients, the age-standardized rate of benzodiazepine-related toxicity per 100,000 population decreased from 27.8 to 26.4 between 2013 and 2020. Clinicians should educate patients about the signs and symptoms of toxicity, “including extreme […]

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Research sheds light on continuous development of social understanding from adolescence into early adulthood

The capability to reflect on their own mental state and that of others continues to develop throughout adolescence, with mentalizing scores varying by gender and personality traits, according to a new study published this week in the open-access journal PLOS ONE by Alex Desatnik of University College London, UK, and colleagues. It has been established that the human brain undergoes […]

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Chris Whitty defends 'morbid' SAGE worst-case models

Dr Doom defends SAGE’s gloom: CMO Chris Whitty tells Covid Inquiry ‘morbid’ SAGE worst-case models that spooked ministers into lockdown are vital for pandemic planning… so we ‘know where to bury the bodies’ Horrifying predictions of upwards of 500,000 deaths spooked No10  READ MORE: Shamed ex-Health Secretary Hancock will be hauled in next week Sir Chris Whitty today defended worst-case scenario […]

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