Despite affecting millions worldwide, Alzheimer’s disease (AD) has long lacked effective treatments due to a fundamental inadequacy of our understanding of its etiology and pathogenesis. The absence of an integrative theory connecting the molecular origins of AD with disturbances at the organelle and cell levels, changes in relevant biomarkers, and population-level prevalence has hindered progress. Even though most scientists only […]

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Following multisystem inflammatory disease in children (MIS-C), cardiac abnormalities are common, regardless of myocardial injury during acute disease, according to a study published online Nov. 15 in Pediatrics. Dayna Zimmerman, M.D., from Children’s Hospital Los Angeles, and colleagues assessed the prevalence of residual cardiovascular pathology by cardiac magnetic resonance imaging (CMR), ambulatory rhythm monitoring, and cardiopulmonary exercise testing (CPET) in […]

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In a recent study published in The Lancet, researchers examine the characteristics, identification, and management of children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) globally. Study: Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study. Image Credit: ridersuperone / Shutterstock.com Background  FH, which affects one in 311 people globally, is a genetic disorder that causes high low-density lipoprotein […]

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New gene-altering jab offers hope to children with drug-resistant epilepsy developed by researchers at University College London Some 600,000 people in Britain suffer from epilepsy, suffering regular seizures The new jab can help children with a specific drug resistant form of epilepsy Scientists have developed a gene therapy to cure a drug-resistant form of childhood epilepsy. Focal cortical dysplasia occurs […]

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Researchers have sequenced the genome of the small but mighty chia seed. The mapping identified numerous genes linked to the health benefits of chia seeds. Researchers say understanding the chia seed genome could pave the way for future treatments for high blood pressure and cancer. Plants are often the source of pharmaceutical drugs, and new insights from genomic databases such […]

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More than a decade ago, the U.S. Department of Veterans Affairs launched a national initiative, termed Whole Health, that takes a holistic approach to health care, emphasizing personalized care plans that address the physical, mental, and emotional well-being of veterans. Earlier this year, the National Academies of Science, Engineering, and Medicine (NASEM) published a consensus report titled “Achieving Whole Health: […]

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Lorraine: Dr Hilary warns of potential rise in Covid cases People infected with a certain strain of Covid could “take longer to recover” a GP has warned. The JN.1 variant, first identified by health officials in September, has the potential to cause a “more severe disease”, he said. As reported, JN.1 is a descendant of BA.2.86, better known as the […]

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Reviewed UCL researchers have developed a new gene therapy to cure a devastating form of childhood epilepsy, which a new study shows can significantly reduce seizures in mice. The study, published in Brain, sought to find an alternative to surgery for children with focal cortical dysplasia. Focal cortical dysplasia is caused by areas of the brain that have developed abnormally […]

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In a novel study, researchers from the Icahn School of Medicine at Mount Sinai have introduced LoGoFunc, an advanced computational tool that predicts pathogenic gain and loss-of-function variants across the genome. Unlike current methods that predominantly focus on loss of function, LoGoFunc distinguishes among different types of harmful mutations, offering potentially valuable insights into diverse disease outcomes. The findings are […]

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£145million: Staggering cost of Covid Inquiry so far – and it’s still got another three years to run Official figures show the Covid inquiry has spent a total of £56million to date But analysis of government data shows the total value of contracts is £145m  More than £145million of private contracts have already been awarded by the Covid Inquiry — […]

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