Proteasomes are protein-degrading complexes that are important for cancer cell survival. Proteasome inhibitors are commonly used to treat diseases such as multiple myeloma and mantle cell lymphoma. Proteasomes have three different active sites but all current FDA-approved inhibitors preferentially target only one active site, known as β5. Despite their success, these drugs have significant limitations including severe side effects and […]

A heart attack is a serious medical emergency that occurs when blood supply to the heart is blocked. Also known as a myocardial infarction, the most common cause of this is a blood clot. If not treated quickly a heart attack can prove fatal. Therefore, it is important to be aware of any of the tell-tale signs. Some of the […]

Reviewed Researchers at Texas A&M University have already shown that paternal drinking habits prior to conception can have a negative effect on fetal development -; with semen from men who regularly consume alcohol impacting placenta development, fetal alcohol syndrome (FAS)-associated brain and facial defects, and even IVF outcomes. In an article published this month in Andrology, the lab of Dr. […]

Breast cancer is a serious cancer type. Researchers are still seeking to understand potential risk factors for breast cancer and ways to modify risk. Data from a recent study involving mice helped note the unique link between the gut microbiome and mammary gland expression of microRNA. Results further found that consuming flaxseed may influence the link between the gut microbiome […]

Aging is known to be a risk factor for the biological changes that create the dangerous buildup of plaque in arteries called atherosclerosis, and aging also induces a buildup of memory CD8 T cells, a type of immune cell, in mice and humans. While this buildup of plaque leads to the heart attacks and strokes that cause nearly one-third of […]

There appears to be a common understanding that there is a mental health crisis among young people, but has society understood why? As presented at the 2023 Society for Risk Analysis Annual Conference, Gabriel Rubin from Montclair State University conducted 40 interviews with members of Gen Z (as of publication) in an ongoing study about risk factors that have led […]

A Cambridge-led study has shown why many women experience nausea and vomiting during pregnancy—and why some women, including the Duchess of Cambridge, become so sick they need to be admitted to hospital. The culprit is a hormone produced by the fetus—a protein known as GDF15. But how sick the mother feels depends on a combination of how much of the […]

91-year-old Margaret Keenan gets her Covid-19 booster vaccine Getting jabs against a range of diseases will soon be “as easy as booking a cab”, the NHS has promised. Easier access to vaccine records via the NHS app and one-stop-shops where people can get their shots alongside other health checks are among measures set out in a new vaccination strategy on […]

Reviewed Identifying an older patient who is at risk for post-operative cognitive dysfunction might be done in the blink of an eye – literally. Researchers at Duke Health found that a simple EEG measurement detects a signal of cognitive vulnerability when patients are asked to close, then open their eyes. Conducted prior to surgery, the non-invasive readout of brain waves […]

Pfizer announced Tuesday that it expects to complete this week its $43 billion acquisition of cancer-focused biotech company Seagen after clearing key regulatory hurdles. “Pfizer and Seagen have now received all required regulatory approvals,” Pfizer said in a news release that reported a key US antitrust waiting period had expired. “Pfizer expects to close the acquisition of Seagen on December […]