Uridine is not only a central building block of RNA, but can also increase the feeling of hunger when ingested, as researchers at the Max Planck Institute for Metabolism Research and the University Hospital of Cologne have now shown. In the long term, uridine could be a potential target for therapeutics against eating disorders in humans. Uridine is known primarily […]

Like many skiers, Dr. Ouida Brown can’t narrow her love of the sport down to just one element. “I love the scenery,” said the orthopedic surgeon from Chicago. “I love the people.” She loves being the first to make tracks in fresh powder in the morning. She loves the physical and mental challenge of trying to improve her time on […]

Getting away for a vacation can help couples rekindle the romance in their lives, according to a survey conducted by OnePoll for BeachBound. What to Know A survey of 2000 adults regarding the magic of vacationing found that three quarters of respondents believed vacations are great for those looking to keep the spark alive in their relationship. Forty-two percent of […]

Examining protein changes in peripheral blood cells just 24 hours after initiating chemotherapy for acute myeloid leukemia (AML) could predict 5-year overall survival, potentially allowing treatment to be changed, say Norwegian researchers. They studied peripheral blood samples from patients with AML and healthy controls, finding that there were several clusters of cells that were different between the two groups, with […]

The researchers screened a library of drugs using a mouse endothelial cell line to identify pathways that are involved in the regulation of Robo4 and found that two competitive SMAD signaling pathways appear to regulate Robo4 expression. When the researchers treated LPS-injected mice with a drug that inhibits ALK1-SMAD signaling, they observed increased Robo4 expression, decreased vascular permeability, and reduced […]

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Nitrites and nitrates occur naturally in water and soil and are commonly ingested from drinking water and dietary sources. They are also used as food additives to increase shelf life. A study publishing January 17th in the open access journal PLOS Medicine by Bernard Srour of the Nutritional Epidemiology Research Team (EREN-CRESS) of Inserm, INRAE, Cnam, and Sorbonne Paris Nord […]

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Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. Women infected with COVID-19 during pregnancy are seven times more likely to die during childbirth or during the pregnancy than uninfected pregnant women, a new study shows. The new report also warns of many other severe complications linked with the virus during pregnancy, as well as […]

In a recent study published in Scientific Reports, researchers developed a computational workflow based on molecular dynamic (MD) simulations and artificial neural network (ANN) to assess the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein receptor-binding domain (RBD)-human angiotensin-converting enzyme 2 (hACE2) binding affinities of SARS-CoV-2 variants. Study: Optimizing variant-specific therapeutic SARS-CoV-2 decoys using deep-learning-guided molecular dynamics simulations. […]