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Since health officials confirmed the first COVID-19 cases, misinformation has spread just as quickly as the virus. Social media may have made the amount, is lexapro ok to take while breastfeeding variety and speed of misinformation seem unprecedented, but COVID-19 isn’t the first pandemic where false and harmful information has set back public health.

Misinformation altered how people trusted their governments and doctors during the 1918 influenza pandemic. It fueled the 19th century smallpox anti-vaccine movements through some of the same arguments as those currently used against the COVID-19 vaccine.

What sets the COVID-19 pandemic apart, however, is the sheer magnitude of damaging disinformation put in circulation around the world. Data shows that regions and countries where disinformation thrived experienced more lethal pandemic waves despite vaccine availability. In the U.S., for example, viewership of a Fox News program that downplayed the pandemic is associated with increased COVID-19 cases and deaths. Similarly in Romania, disinformation is a contributing factor to the country’s disastrous fourth wave of COVID-19.

The problem of misinformation has been so widespread that it has its own word: “infodemic,” a portmanteau of “information” and “epidemic.” Coined by journalist David Rothkopf during the 2003 SARS outbreak, it describes a situation where “a few facts, mixed with fear, speculation and rumor, are amplified and relayed swiftly worldwide by modern information technologies.”

Infodemics can affect economies, politics, national security and public health. The COVID-19 infodemic became such a problem that the Royal Society and the British Academy released an October 2020 report noting its significant impact on vaccine deployment, endorsing legislation that prosecutes those who spread misinformation.

As a researcher who studies HIV and lived through the AIDS pandemic, I felt a sense of déjà vu as COVID-19 disinformation spread. In the 40 years since the emergence of AIDS, society has learned how to cope with the disease with more effective diagnostics, treatments and preventive strategies, transforming AIDS from a lethal condition to a chronic disease.

However, there are striking parallels between the HIV/AIDS and COVID-19 pandemics that show the dire consequences disinformation can have on both patients and society as a whole.

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Denying the existence of a virus or a pandemic

There are people who deny the existence of COVID-19. There are abundant claims on social media that the virus that causes COVID-19 has never been isolated, or it is insufficiently characterized. Others do not contest the existence of COVID-19, but ignore the severe consequences of infection.

In general, these groups tend to also deny germ theory, claiming that infectious diseases are not caused by pathogens like viruses and bacteria. Instead, they promote the idea that pathogens don’t cause disease, but rather are a consequence of it.

Likewise, some denied the role of the HIV virus in AIDS infection. AIDS denialist Peter Duesberg was one person who disseminated this misinformation, which had been refuted by the scientific community at large. But his erroneous claim still reached the then president of the Republic of South Africa, Thabo Mbeki, who banned the use of lifesaving antiretrovirals in public hospitals. This decision resulted in the deaths of over 330,000 people from HIV/AIDS between 2000 and 2005.

Mbeki’s decision was considered so damaging that scientists and physicians worldwide signed the Durban Declaration, reiterating that HIV indeed causes AIDS and urging Mbeki to reconsider his decision. While the government did reverse the ban after strong international political pressure, the damage had been done.

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Gain of function claims

Gain of function experiments involve manipulating a pathogen to understand what contributes to its ability to cause disease. At the same time, such experiments can give pathogens new abilities, such as making viruses more transmissible or more dangerous to humans. Conspiracy theorists have made claims that the COVID-19 virus resulted from alterations to a bat version of the virus that gave it the ability to replicate in human cells.

But these claims ignore several key facts about the COVID-19 virus, including that all coronaviruses from bats can infect humans without additional adaptation. The mutations that increased the transmissibility of COVID-19 occurred after it started circulating in people, resulting in even more infectious variants.

HIV also saw conspiracy theories claiming that it was created in a lab for genocide. But research has shown that HIV also naturally evolved from an animals. African non-human primates are natural hosts to a vast group of viruses collectively called simian immunodeficiency viruses (SIV). Despite their high rates of SIV infection in the wild, these primate hosts typically don’t experience symptoms or progress to AIDS. Throughout the evolutionary history of SIV, jumping to a new host species involved naturally occurring genetic changes over the course of thousands of years.

Miracle cures

During a public health crisis, researchers and health officials are learning about a disease in real time. While missteps are expected, these can be perceived by the public as hesitation, incompetence or failure.

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As researchers looked for possible COVID-19 treatments, others were offering their own unproven drugs. Multiple treatments for COVID-19, including ivermectin and hydroxychloroquine, were tested and abandoned. But not before large amounts of time, effort and money were spent on disproving claims that these were supposed miracle treatments. Similarly for HIV, frustration and anxiety from a continued lack of available treatments amid rising deaths led to fraudulent cures, with price tags of tens of thousands of dollars.

Even though treatment delays and changing guidelines are a natural process of learning about a new diseases as it unfolds, they can open the door to disinformation and generate distrust in doctors even as they care for infected patients.

Preventing misinfodemics

The next pandemic is not a question of if but when and where it will occur. Just as important as devising ways to detect emerging viruses is developing strategies to address the misinfodemics that will follow them. The recent monkeypox outbreak has already seen similar spread of mis- and disinformation about its source and spread.

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