Coronaviruses: Symptoms, treatments, and variants

Coronaviruses are types of viruses that typically affect the respiratory tract of mammals, including humans. They are associated with the common cold, pneumonia, and severe acute respiratory syndrome (SARS) and can also affect the gut.

A coronavirus was first isolated in 1937 from an infectious bronchitis virus in birds that has the ability to seriously devastate poultry stocks.

These viruses are responsible for between 15 and 30 percent of common colds.

Over the last 70 years, scientists have found that coronaviruses can infect mice, rats, dogs, cats, turkeys, horses, pigs, and cattle. Most recently, authorities identified a coronavirus outbreak in China that has now reached other countries.

This MNT Knowledge Center article will focus on the different types of human coronaviruses, their symptoms, how they are transmitted, and two particularly dangerous diseases that can be caused by coronaviruses: SARS and MERS.

Fast facts on coronaviruses

• There is no cure for the common cold.
• A coronavirus causes both SARS and MERS.
• Coronaviruses infect many different species.
• There are seven known human coronaviruses.
• SARS spread from China to cause infection in 37 countries, killing 774 people.

What are coronaviruses?

Human coronaviruses (HCoV) were first identified in the 1960s in the noses of patients with the common cold. Two human coronaviruses are responsible for a large proportion of common colds OC43 and 229E.

Coronaviruses were given their name based on the crown-like projections on their surfaces. “Corona” in Latin means “halo” or “crown.”

Among humans, infection most often occurs during the winter months as well as early spring. It is not uncommon for a person to become ill with a cold that is caused by a coronavirus and then catch it again about four months later.

This is because coronavirus antibodies do not last for a very long time. Also, the antibodies for one strain of coronavirus may be useless against other strains.

Symptoms

Cold- or flu-like symptoms usually set in from two to four days after coronavirus infection, and they are typically mild. However, symptoms vary from person to person, and some forms of the virus can be fatal.

Symptoms include:

• sneezing
• a runny nose
• fatigue
• a cough
• in rare cases, fever
• a sore throat
• exacerbated asthma

Human coronaviruses cannot be cultivated in the laboratory easily, unlike the rhinovirus, another cause of the common cold. This makes it difficult to gauge the coronavirus’ impact on national economies and public health.

There is no cure, so treatments include taking care of yourself and over-the-counter (OTC) medication:

• Rest and avoid overexertion.
• Drink enough water.
• Avoid smoking and smoky areas.
• Take acetaminophen, ibuprofen or naproxen to reduce pain and fever.
• Use a clean humidifier or cool mist vaporizer.

The virus responsible can be diagnosed by taking a sample of respiratory fluids, such as mucus from the nose, or blood.

Types

Different types of human coronaviruses vary in the severity of illness they cause and how far they can spread.

There are currently seven recognized types of coronavirus that can infect humans.

Common types include:

• 229E (alpha coronavirus)
• NL63 (alpha coronavirus)
• OC43 (beta coronavirus)
• HKU1 (beta coronavirus)

Rarer, more dangerous types include MERS-CoV, which causes Middle East Respiratory Syndrome (MERS), and severe acute respiratory syndrome (SARS-CoV), the coronavirus responsible for SARS. In 2019, a dangerous new strain started circulating, but it does not yet have an official name. Health authorities are currently referring to it as 2019 Novel Coronavirus (2019-nCov).

Transmission

There has not been a great deal of research on how a human coronavirus spreads from one person to the next.

However, it is believed that the viruses transmit using secreted fluid from the respiratory system.

Coronaviruses can spread in the following ways:

• Coughing and sneezing without covering the mouth can disperse droplets into the air, spreading the virus.
• Touching or shaking hands with a person that has the virus can pass the virus from one person to another.
• Making contact with a surface or object that has the virus and then touching your nose, eyes, or mouth.
• On rare occasions, a coronavirus may spread through contact with feces.

People in the U.S. are more likely to contract the disease in the winter or fall. The disease is still active during the rest of the year. Young people are most likely to contract a coronavirus, and people can contract more than one infection over the course of a lifetime. Most people will become infected with at least one coronavirus in their life.

It is said that the mutating abilities of the coronavirus are what make it so contagious.

To prevent transmission, be sure to stay at home and rest while experiencing symptoms and avoid close contact with other people. Covering the mouth and nose with a tissue or handkerchief while coughing or sneezing can also help prevent the spread of a coronavirus. Be sure to dispose of any used tissues and maintain hygiene around the home.

2019-nCov

In 2019, the Centers for Disease Control and Prevention (CDC) started monitoring the outbreak of a new coronavirus. Authorities first identified the virus in Wuhan, China. They have named it 2019 Novel Coronavirus (2019-nCov).

More than 1,000 people have contracted the virus in China. Health authorities have identified several other people with 2019-nCov around the world, including multiple individuals in the United States. On January 31, 2020, the virus passed from one person to another in the U.S. The World Health Organization (WHO) have declared a public health emergency relating to 2019-nCov.

Since then, 2019-nCov has started causing disruption in 24 other countries. In the United Kingdom on February 10, 2020, a clinic in Brighton closed temporarily after a member of staff contracted the virus. At the time of writing, they are one of eight people with the virus.

Some of the first people with 2019-nCov had links to an animal and seafood market. This initially suggested that animals transmit the virus to humans. However, people with a more recent diagnosis had no connections with or exposure to the market, suggesting that humans can pass the virus to each other.

Information on the virus is scarce at present. In the past, respiratory conditions that develop from coronaviruses, such as SARS and MERS, have spread through close contacts.

However, while some viruses are highly contagious, it is less clear with coronaviruses as to how rapidly they will spread.

Symptoms vary from person to person with a 2019-nCov infection. It may produce few or no symptoms. However, it can also lead to severe illness and may be fatal. Common symptoms include:

• fever
• breathlessness
• cough

It may take 2–14 days for a person to notice symptoms after infection.

No vaccine is currently available for 2019-nCov. However, scientists have replicated the virus. This could allow for early detection and treatment in people who have the virus but are not yet showing symptoms.

SARS

Severe acute respiratory syndrome (SARS) was a contagious disease caused by the SARS-CoV coronavirus. It typically led to a life-threatening form of pneumonia.

The virus started off in the Guangdong Province in southern China in November 2002, eventually reaching Hong Kong. From there, it rapidly spread around the world, infecting people in 37 countries.

SARS-CoV is unique. It can infect both the upper and lower respiratory tract and can also cause gastroenteritis.

The symptoms of SARS develop over the course of a week and start with a fever. Early on in the condition, people develop flu-like symptoms, such as:

• dry coughing
• chills
• diarrhea
• breathlessness
• aches

Pneumonia, a severe lung infection, may develop afterward. At its most advanced stage, SARS causes failure of the lungs, heart, or liver.

During the epidemic, there were 8,098 confirmed cases of SARS with 774 fatalities. This is equal to a mortality rate of 9.6 percent. Complications were more likely in older adults, and half of all infected people over the age of 65 years who became ill did not survive. It was eventually brought under control in July 2003.

MERS

MERS, caused by the MERS-CoV coronavirus, was first recognized in 2012. This severe respiratory illness first surfaced in Saudi Arabia and, since then, has spread to other countries. The virus has reached the U.S., and the largest outbreak outside the Arabian Peninsula occurred in South Korea in 2015.

Symptoms include fever, breathlessness, and coughing. The illness spreads through close contact with people who have already been infected. However, all cases of MERS are linked to individuals who have recently returned from travel to the Arabian Peninsula.

MERS is fatal in 30 to 40 percent of people who contract it.

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