COVID-19: These drugs do not act however, Naturopathy naturopathic specialist portal

Trumps Corona-wonder doesn’t work

U.S. President Donald Trump and the President of Brazil Bolsonaro swear in the fight against COVID-19 on the controversial means of hydroxychloroquine. However, Researchers report that the Malaria drug works against the Coronavirus SARS-CoV-2 induced disease. The same also applies to a further active ingredient, regarded as a beacon of hope against the disease.

The Malaria drug hydroxychloroquine belonged to for many professionals to be the most promising drug candidates in the search for a COVID-19-therapy. But months ago, Researchers reported that this medium brings more harm than good, and even a risk for deadly side effects carries. And according to a research team from Switzerland are not affected at all by the Coronavirus SARS-CoV-2 induced disease.

Concentration of the drugs is not enough

How the University of Basel explains in a recent communication, Lopinavir, a drug against HIV and hydroxychloroquine used in Malaria, and rheumatism. Both ingredients were considered until Recently as a potential carrier of hope in the fight against the Coronavirus SARS-CoV-2.

However, a research group of the University and University hospital of Basel has now found that the concentration of two drugs in the lungs of COVID-19-Ill is not sufficient to combat the Virus.

Virus replication is probably inhibited

Since February 2020 studies at the University and Basel University hospital with patients who are severely ill with COVID-19 run. The research group of infectious diseases studied how the SARS-CoV-2-induced inflammation affects the concentration of drugs in the blood.

“Previous research has shown that the drug metabolism may be inhibited by inflammation,” explains Prof. Dr. Catia Marzolini, a Professor of Experimental medicine and first author of the Basel study. “We wanted to investigate the effect of inflammation on the concentration of Lopinavir and hydroxychloroquine in the blood.” According to the experts can occur in a strong inhibition of very high drug concentration in the body.

The Recently in the journal “Antimicrobial Agents and Chemotherapy” published study has shown that the concentration of the HIV drug Lopinavir is in fact linked to the intensity of the inflammation, together.

The scientists have calculated from the drug concentration in the blood, the concentration of Lopinavir and hydroxychloroquine must have been in the lung at the site of infection with SARS-CoV-2. According to the results, it is unlikely that both drugs can reach sufficient concentrations to inhibit the virus replication in the lungs.

Study should not be continued

The world health organization (WHO) has on 4. July 2020 decided that a study with hydroxy-chloroquine and Lopinavir/Ritonavir for COVID-is not to be continued 19. “The results of our own study provide important scientific insights that are in line with this decision, and explain why these drugs work,” said Professor Manuel Battegay Professor of infectious diseases at the University of Basel and head of the clinic of infectious diseases & Hospital hygiene at the University hospital Basel. (ad)

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